Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini 英文参考文献.docVIP

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Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini 英文参考文献.doc

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Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini 英文参考文献

Essay Self-OrganizationandRegulationofIntrinsically DisorderedProteinswithFoldedN-Termini PhilipC.Simister1,FredSchaper2,NicolaO’Reilly3,SimonMcGowan4,StephanM.Feller1* 1Cell Signalling Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom, 2Department of Systems Biology,Otto-von-Guericke-UniversityMagdeburg,Magdeburg,Germany,3PeptideSynthesisLaboratory,CancerResearchUKLondonResearchInstitute,London,United Kingdom,4ComputationalBiologyResearchGroup,WeatherallInstituteofMolecularMedicine,JohnRadcliffeHospital,UniversityofOxford,Oxford,UnitedKingdom Summary conformational changes that presumably occurduringtheirinteractions withother proteins. Nevertheless, ID proteins have importantfunctionsinmulti-proteincom- plex assembly and cell signalling [4–7], and we need to learn much more about theirmolecularactivitiesandmechanisms ofactionaswellastheirstructures. recognized by current secondary or ter- tiary structure prediction programmes, which primarily recognize a-helices and b-strands and higher order assemblies built from these. Examples of secondary structure elements that are usually not detected include the poly-proline type II (PPII) [19,20] and 310 helices [21,22]. Herewehypothesizethatsomeproteins use their structured N-terminal domains (SNTDs)toorganizetheremainingprotein chain by means of intramolecular interac- tions, so generating partially condensed proteins. This model has several attractive features: as the nascent protein chain emerges from the ribosome, the SNTD folds spontaneously and then serves as a nucleation point for the yet unstructured amino acid chain, creating more compact shapes. This reduces the risk of protein degradation or aggregation. Moreover, an interspersed pattern of SNTD-docked re- gionsandfreeloopscancoordinateassem- bly of sub-complexes in defined loop- sectionsandenablesnovelregulatorymech- anisms, for example through posttransla- tionalmodificationsofdock