Sensitive Detection of Haloperidol and Hydroxyzine at Multi-Walled Carbon Nanotubes-Modified Glassy Carbon Electrodes 英文参考文献.docVIP

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Sensitive Detection of Haloperidol and Hydroxyzine at Multi-Walled Carbon Nanotubes-Modified Glassy Carbon Electrodes 英文参考文献.doc

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Sensitive Detection of Haloperidol and Hydroxyzine at Multi-Walled Carbon Nanotubes-Modified Glassy Carbon Electrodes 英文参考文献

Sensors 2008, 8, 1879-1889 sensors ISSN 1424-8220 ? 2008 by MDPI /sensors Review Sensitive Detection of Haloperidol and Hydroxyzine at Multi-Walled Carbon Nanotubes-Modified Glassy Carbon Electrodes Fei Huang, Youyuan Peng, Guiying Jin, Song Zhang and Jilie Kong* Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P.R. China *Author to whom correspondence should be addressed; E-mail: jlkong@ Received: 1 February 2008 / Accepted: 14 March 2008 / Published: 17 March 2008 Abstract: Haloperidol (i.e. HPD) and hydroxyzine (i.e. HXY), two effective and important tranquilizers with low redox activity, were found to generate an irreversible anodic peak at about +0.86 V (vs. SCE) or two anodic peaks at about +0.83 and +0.91 V in 0.05 M NaH2PO4-Na2HPO4 (pH=7.0) buffer solution with a multi-walled carbon nanotubes-modified glassy carbon electrode (i.e. MWNTs/GC), respectively. Their sensitive and quantitative measurement based on the first two anodic peaks was established under the optimum conditions. The anodic peak current was linear to HPD and HXY concentration from 1×10-7 to 2.5 ×10-5 M and 5×10-8 to 2.5 ×10-5 M, the detection limits obtained were 8×10-9 and 5×10-9 M, separately. The modified electrode exhibited some excellent characteristics including easy regeneration, high stability, good reproducibility and selectivity. The method proposed was successfully applied to the detection of HPD and HXY in drug tablets and proved to be reliable compared with ultraviolet spectrophotometry. The modified electrode was characterized by electrochemical methods. Keywords: Haloperidol, Hydroxyzine, Multi-walled carbon nanotubes, Detection, Excellent characteristics, Characterization. Sensors 2008, 8 1880 1. Introduction As two effective and important tranquilizers, haloperidol and hydroxyzine (Scheme 1) are widely used in the treatment of schizophrenia