Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene a prospective observational study 英文参考文献.docVIP

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Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene a prospective observational study 英文参考文献.doc

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Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene a prospective observational study 英文参考文献

Available online /content/10/5/R139 Research Open Access Vol 10 No 5 Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study Michael J ODwyer1,2, Felicity Dempsey3, Vivion Crowley3, Dermot P Kelleher2, Ross McManus2 and Thomas Ryan1 1Department of Anaesthesia, St Jamess Hospital, Jamess St, Dublin, D7, Ireland 2Department of Clinical Medicine, Trinity College, Dublin, D2, Ireland 3Department of Clinical Chemistry, St Jamess Hospital, Jamess St, Dublin, D7, Ireland Corresponding author: Michael J ODwyer, modwyer18@ Received: 10 Jul 2006 Revisions requested: 10 Aug 2006 Revisions received: 16 Aug 2006 Accepted: 26 Sep 2006 Published: 26 Sep 2006 Critical Care 2006, 10:R139 (doi:10.1186/cc5053) This article is online at: /content/10/5/R139 ? 2006 ODwyer et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Asymmetrical dimethyl arginine (ADMA) is an endogenous non-selective inhibitor of nitric oxide synthase that may influence the severity of organ failure and the occurrence of shock secondary to an infectious insult. Levels may be genetically determined by a promoter polymorphism in a Results On day 1 more ADMA was detectable in the ICU group than in the control group (p = 0.005). Levels subsequently increased during the first week in ICU (p = 0.001). ADMA levels were associated with vasopressor requirements on day one (p = 0.001). ADMA levels and Sequential Organ Failure regulatory gene encoding dimethylarginine Assessment scores were directly associated on day one (p = 0.0001) and day seven (p = 0.002). T