Sequential Loading of Cohesin Subunits during the First Meiotic Prophase of Grasshoppers 英文参考文献.docVIP

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Sequential Loading of Cohesin Subunits during the First Meiotic Prophase of Grasshoppers 英文参考文献.doc

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Sequential Loading of Cohesin Subunits during the First Meiotic Prophase of Grasshoppers 英文参考文献

SequentialLoadingofCohesinSubunits duringtheFirstMeioticProphase ofGrasshoppers Ana M.Valdeolmillos2[,Alberto Viera1[,Jesu′sPage1,Ignacio Prieto2,Juan L.Santos3,Mar?′aTeresa Parra1, Margarete M. S.Heck4,Carlos Mart?′nez-A2,Jose′ L.Barbero5,Jose′ A.Suja1,Julio S.Rufas1* 1 Departamento de Biolog?′a, Edificio de Biolo′gicas, Universidad Auto′noma de Madrid, Madrid, Spain, 2 Department of Immunology and Oncology, Centro Nacional de Biotecnolog?′a,Madrid,Spain,3DepartamentodeGene′tica,FacultaddeBiolog?′a,UniversidadComplutense,Madrid,Spain,4WellcomeTrustCentreforCellBiology,Institute of Cell Biology, University of Edinburgh, Edinburgh, United Kingdom, 5 Departamento de Biolog?′a Celular y del Desarrollo, Centro de Investigaciones Biologicas (CSIC), Madrid,Spain Thecohesincomplexes playakeyroleinchromosomesegregationduringbothmitosisandmeiosis.Theyestablish sisterchromatidcohesionbetweenduplicatingDNAmoleculesduringS-phase,buttheyalsohaveanimportantrole during postreplicative double-strand break repair in mitosis, as well as during recombination between homologous chromosomesinmeiosis.Anadditionalfunctioninmeiosisisrelatedtothesisterkinetochorecohesion,sotheycanbe pulledbymicrotubulestothesamepoleatanaphaseI.Dataaboutthedynamicsofcohesinsubunitsduringmeiosis arescarce;therefore,itisofgreatinteresttocharacterizehowtheformationofthecohesincomplexesisachievedin order to understand the roles of the different subunits within them. We have investigated the spatio-temporal distribution of three different cohesin subunits in prophase I grasshopper spermatocytes. We found that structural maintenance of chromosome protein 3 (SMC3) appears as early as preleptotene, and its localization resembles the locationoftheunsynapsedaxialelements,whereasradiation-sensitivemutant21(RAD21)(sisterchromatidcohesion protein 1, SCC1) and stromal antigen protein 1 (SA1) (sister chromatid cohesion protein 3, SCC3) are not visualized untilzygotene,sincetheyarelocatedinthesynapsedregionsofthe