Severe influenza A (H1N1)v in patients without any known risk factor 英文参考文献.docVIP

Available online /content/13/6/425 Letter Severe influenza A (H1N1)v in patients without any known risk factor Carles Alonso-Tarrés, Cristina Cortes-Lletget, Sara Pintado and Assumpta Ricart Microbiology-Consorci de Laboratoris Intercomarcal, Hospital General de l’Hospitalet, Avda. Josep Molins, 29-41, L’Hospitalet de Llobregat, Barcelona 08906, Spain Corresponding author: Carles Alonso-Tarrés, carlesmicro@ Published: 19 November 2009 Critical Care 2009, 13:425 (doi:10.1186/cc8150) This article is online at /content/13/6/425 ? 2009 BioMed Central Ltd See related research by Rello et al., /content/13/5/R148 A proportion of pandemic flu cases requires critical care. Several risk factors are associated with progressive illness. The World Health Organization recommends prompt antiviral treatment when risk factors are present [1]. Nevertheless, in Rello and colleagues’ work, 15 out of 32 critical pandemic flu patients did not have any risk factor [2]. antiviral treatment in the first 48 hours of symptoms (Fisher’s exact test P = 0.009). In Rello and colleagues’ study, the median number of days from illness onset to initiation of antiviral treatment was 4 days. Patients with risk factors were probably treated immediately, however, and patients without any risk factors were probably treated later. Some evidence suggests that early antiviral treatment is associated with a good prognosis [3]. Rello and colleagues may provide the mean of treatment delay days in patients without any risk factor and any putative differences with the rest of patients. Early antiviral treatment with active antiviral drugs may prevent severe cases in patients without any risk factor. The authors may also inform about any other difference in this group of patients. In our hospital, 25 pandemic flu cases have been diagnosed by RT-PCR thus far.