SGC - Structural Biology and Human Health A New Approach to Publishing Structural Biology Results 英文参考文献.docVIP

Overview SGC-StructuralBiologyandHumanHealth:ANew ApproachtoPublishingStructuralBiologyResults WenHwaLee1*,Julia′nAtienza-Herrero1,RubenAbagyan2,3,BrianD.Marsden1,4 1SGC,UniversityofOxford,Headington,Oxford,UnitedKingdom,2SkaggsSchoolofPharmacyandPharmaceuticalSciences,UniversityofCaliforniaSanDiego,LaJolla, California, United States of America, 3Molsoft LLC, La Jolla, San Diego, California, United States of America, 4Nuffield Department of Clinical Medicine University of Oxford,Headington,Oxford,UnitedKingdom The Structural Genomics Consortium (SGC) is a not-for-profit, public-private partnership established to deliver novel structuralbiologyknowledgeonproteinsof medical relevance and place this informa- tionintothepublicdomainwithoutrestric- tion, spearheading the concept of ‘‘Open- Source Science’’ to enable drug discovery. TheSGCisamajorproviderofstructural informationfocussedonproteinsrelatedto humanhealth,contributing20.5%ofnovel structuresreleasedbythePDBin2008.In this article we describe the PLoS ONE Collection entitled ‘Structural Biology and Human Health: Medically Relevant Pro- teins from the SGC’. This Collection contains a series of articles documenting manyofthenovelproteinstructuresdeter- mined by the SGC and work to further characterise their function. Each article in thisCollectioncanbereadinanenhanced version where we have integrated our interactive and intuitive 3D visualisation platform, known as iSee. This publishing platform enables the communication of complexstructuralbiologyandrelateddata toawideaudienceofnon-structuralbiolo- gists. With the use of iSee as the first exampleofaninteractiveandintuitive3D document publication method as part of PLoSONE,wearepushingtheboundaries ofstructuralbiologydatadeliveryandpeer- review. Our strong desire is that this step forward will encourage others to consider theneedforpublicationofthreedimension- alandassociateddatainasimilarmanner. case manner, with academic researchers specific protocols over