Shaping the future of interactome networks 英文参考文献.docVIP

Meeting report Shaping the future of interactome networks Patrick Aloy Addresses: Institute for Research in Biomedicine (IRB), c/ Josep Samitier 1-5, 08028 Barcelona, Spain, and Institució Catalana de Recerca i Estudis Avan?ats (ICREA), Passeig Lluis Companys 23, 08010 Barcelona, Spain. Published: 1 November 2007 Genome Biology 2007, 8:316 (doi:10.1186/gb-2007-8-10-316) The electronic version of this article is the complete one and can be found online at /2007/8/10/316 ? 2007 BioMed Central Ltd assays. He and Pascal Braun (Dana-Farber Cancer Institute) A report of the third Interactome Networks Conference, Hinxton, UK, 29 August-1 September 2007. also showed that in an ideal scenario a two-hybrid experiment would be able to detect roughly 25% of the total number of possible interactions. However, the typical cover- age of a single screen is only about 10%, and one would have to repeat the same experiment six times to reach the upper coverage limit of 25%. These criteria were used to estimate that there would be approximately 280,000 protein-protein binary interactions in humans, without including splice variants. Anne-Claude Gavin (European Molecular Biology Complex systems are often networked, and biology is no exception. Following on from the genome sequencing projects, experiments show that proteins in living organisms are highly connected, which helps to explain how such great complexity can be achieved by a comparatively small set of gene products. At a recent conference on interactome networks held outside Cambridge, UK, the most recent advances in research on cellular networks were discussed. At previous meetings in this series we heard much about the abstract properties of biological networks, often with little application to day-to-day biology, and the achievement of amazing milestones such as the first drafts of human interactomes or the completion of affi