Shared “Core” Areas between the Pain and Other Task-Related Networks 英文参考文献.docVIP

Shared‘‘Core’’AreasbetweenthePainandOtherTask- RelatedNetworks FrancoCauda1,2*,DianaM-E.Torta2,KatiusciaSacco1,2,ElisabettaGeda1,FedericoD’Agata1,2,3, TommasoCosta2,SergioDuca1,GiulianoGeminiani1,2,MartinaAmanzio2,4 1CCSfMRI,KoellikerHospital,Turin,Italy,2DepartmentofPsychology,UniversityofTurin,Turin,Italy,3DepartmentofNeuroscience,AOUSanGiovanniBattista,Turin, Italy,4NeuroscienceInstituteofTurin(NIT),UniversityofTurin,Italy Abstract The idea of a‘pain matrix’ specifically devoted to the processing of nociceptive inputs has been challenged. Alternative viewsnowproposethattheactivityoftheprimaryandsecondarysomatosensorycortices(SI,SII),theinsulaandcingulate cortexmayberelatedtoabasicdefensivesystemthroughwhichsignificantpotentiallydangerouseventsforthebody’s integrity are detected. By reviewing the role of the SI, SII, the cingulate and the insular cortices in the perception of nociceptiveandtactilestimuli,inattentional,emotionalandrewardtasks,andininteroceptionandmemory,wefoundthat all these task-related networks overlap in the dorsal anterior cingulate cortex, the anterior insula and the dorsal medial thalamus.Athoroughanalysisrevealedthatthe‘pain-related’networksharesimportantfunctionalsimilaritieswithboth somatomotor-somatosensorynetworksandemotional-interoceptiveones.Wesuggestthatthesesharedareasconstitute thecentralpartofanadaptivecontrolsysteminvolvedintheprocessingandintegrationofsalientinformationcomingboth from external and internal sources. These areas are activated in almost all fMRI tasks andhave been indicated to play a pivotalroleinswitchingbetweenexternallydirectedandinternallydirectedbrainnetworks. Citation:CaudaF,TortaDM-E,SaccoK,GedaE,D’AgataF,etal.(2012)Shared‘‘Core’’AreasbetweenthePainandOtherTask-RelatedNetworks.PLoSONE7(8): e41929.doi:10.1371/journal.pone.0041929 Editor:DanteR.Chialvo,NationalResearchTechnologyCouncil,Argentina ReceivedFebruary3,2012;AcceptedJune29,2012;PublishedAugust10,2012 Copyright: ? 2012 Cauda et al. This is an open-ac