Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men Findings from the Whitehall II Cohort Study 英文参考文献.docVIP

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Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men Findings from the Whitehall II Cohort Study 英文参考文献.doc

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Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men Findings from the Whitehall II Cohort Study 英文参考文献

ShortSleepDurationIsAssociatedwithShorter TelomereLengthinHealthyMen:Findingsfromthe WhitehallIICohortStudy MartaJackowska1*,MarkHamer1,LiviaA.Carvalho1,JorgeD.Erusalimsky2,LeeButcher2, AndrewSteptoe1 1ResearchDepartmentofEpidemiologyandPublicHealth,UniversityCollegeLondon,London,UnitedKingdom,2CardiffSchoolofHealthSciences,CardiffMetropolitan University,Cardiff,UnitedKingdom Abstract Background:Shortertelomerelengthandpoorsleeparemoreprevalentatolderages,buttheirrelationshipisuncertain. Thisstudyexploredassociationsbetweensleepdurationandtelomerelengthinasampleofhealthymiddleandearlyold agepeople. Methods:Participants were434menandwomenaged63.3yearsonaveragedrawnfromtheWhitehallII cohortstudy. Sleepdurationwasmeasuredbyself-report. Results:Therewasalinearassociationbetweensleepdurationandleukocytetelomerelengthinmenbutnotinwomen (P=0.035).Menreportingshortersleepdurationhadshortertelomeres,independentlyofage,bodymassindex,smoking, educationalattainment,currentemployment,cynicalhostilityscoresanddepressivesymptoms.Telomereswereonaverage 6%shorterinmensleeping5hoursorfewercomparedwiththosesleepingmorethan7hourspernight. Conclusion:Thisstudyaddstothegrowingliteraturerelatingsleepdurationwithbiomarkersofaging,andsuggeststhat shortening of telomeres might reflect mechanisms through which short sleep contributes to pathological conditions in oldermen. Citation:JackowskaM,HamerM,CarvalhoLA,ErusalimskyJD,ButcherL,etal.(2012)ShortSleepDurationIsAssociatedwithShorterTelomereLengthinHealthy Men:FindingsfromtheWhitehallIICohortStudy.PLoSONE7(10):e47292.doi:10.1371/journal.pone.0047292 Editor:StefanKiechl,InnsbruckMedicalUniversity,Austria ReceivedJuly6,2012;AcceptedSeptember14,2012;PublishedOctober29,2012 Copyright: ? 2012 Jackowska et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: T