Shigellosis Outbreak Associated with Contaminated Well Water in a Rural Elementary School Sichuan Province, China, June 7–16, 2009 英文参考文献.docVIP

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Shigellosis Outbreak Associated with Contaminated Well Water in a Rural Elementary School Sichuan Province, China, June 7–16, 2009 英文参考文献.doc

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Shigellosis Outbreak Associated with Contaminated Well Water in a Rural Elementary School Sichuan Province, China, June 7–16, 2009 英文参考文献

ShigellosisOutbreakAssociatedwithContaminatedWell WaterinaRuralElementarySchool:SichuanProvince, China,June7–16,2009 FanHe1.,KeHan2.,LunguangLiu3.,WeiSun3,LijieZhang4,BaopingZhu4,HuilaiMa4* 1Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, People’s Republic of China, 2Guangdong Provincial Center for Disease Control and Prevention,Guangzhou,People’sRepublicofChina,3SichuanProvincialCenterforDiseaseControlandPrevention,Chengdu,People’sRepublicofChina,4ChineseField EpidemiologyTrainingProgram,ChineseCenterforDiseaseControlandPrevention,Beijing,People’sRepublicofChina Abstract Objectives: We investigated a shigellosis outbreak in an elementary school to identify the source of infection, mode of transmissionandriskfactorsforillness. Methods:Inacase-controlinvestigation,wecomparedthesourceofdrinkingwater,consumptionofuntreatedwellwater and suspected food items, and hygienic habits between case-students and randomly selected asymptomatic control- students,frequency-matchedbyclassona1:1ratio. Results: 18% of the 533 students and no teachers developed Shigella. 52%(44/85) of case-students and 17% (12/71) of control-studentsdrankuntreatedwellwater(OR=2.3,95%CI=1.1–5.8);47%(n=40/85)ofcase-studentsand14%(10/71) ofcontrol-studentsdrankuntreatedwaterfromWellA(OR=3.7,95%CI=1.3–11).Theoddsratioincreasedwiththeamount ofuntreatedWellAwaterconsumed(p=0.035,x2testfortrend).Rectalswabsfrom5of6case-studentsandwaterfrom WellAyieldedShigellaflexneri2b. Conclusions:ThisshigellosisoutbreakwascausedbydrinkinguntreatedwaterfromawellpollutedbyShigellaflexneri2b. Citation:HeF,HanK,LiuL,SunW,ZhangL,etal.(2012)ShigellosisOutbreakAssociatedwithContaminatedWellWaterinaRuralElementarySchool:Sichuan Province,China,June7–16,2009.PLoSONE7(10):e47239.doi:10.1371/journal.pone.0047239 Editor:MartynKirk,TheAustralianNationalUniversity,Australia ReceivedApril23,2012;AcceptedSeptember11,2012;PublishedOctober10,2012 Copyright:?2012Heetal.Thisisanopen-accessarticledistributedunderthete