Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis 英文参考文献.docVIP

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Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis 英文参考文献.doc

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Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis 英文参考文献

Available online /content/11/4/R123 Research article Open Access Vol 11 No 4 Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis Maria Rehnberg, Sylvie Amu, Andrej Tarkowski, Maria I Bokarewa and Mikael Brisslert Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden Corresponding author: Mikael Brisslert, mikael.brisslert@rheuma.gu.se Received: 10 Mar 2009 Revisions requested: 20 Apr 2009 Revisions received: 29 Jul 2009 Accepted: 17 Aug 2009 Published: 17 Aug 2009 Arthritis Research Therapy 2009, 11:R123 (doi:10.1186/ar2789) This article is online at: /content/11/4/R123 ? 2009 Rehnberg et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction In the present study we evaluated changes in the B cell phenotype in peripheral blood and bone marrow (BM) of patients with rheumatoid arthritis (RA) following anti-CD20 treatment using rituximab. CD27+IgD- memory cells, while IgD+ cells were completely depleted. A significant reduction of CD27+ cells in BM and in circulation was observed long after rituximab treatment (mean 22 months), while levels of naive B cells in BM and in circulation were increased. The levels of rheumatoid factor decline after rituximab treatment but returned to baseline levels at the time of retreatment. Methods Blood and BM samples were obtained from 37 patients with RA prior to rituximab treatment. Ten of these patients were resampled 1 month following rituximab, 14 patients after 3 months and the remaining 13 patients were included in the long-term follow up. B cell po