Signals and systems 英文参考文献.docVIP

Meeting report Signals and systems Nevan J Krogan* and Timothy R Hughes? Addresses: *Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA. ?Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. Correspondence: Timothy R Hughes. Email: t.hughes@utoronto.ca Published: 25 April 2006 Genome Biology 2006, 7:313 (doi:10.1186/gb-2006-7-4-313) The electronic version of this article is the complete one and can be found online at /2006/7/4/313 ? 2006 BioMed Central Ltd that there were 16 bases in the interfering RNA that were A report on the 2006 Keystone Conference on Signaling Networks, Vancouver, Canada, 30 January-4 February 2006. identical to armadillo, a known gene in the pathway, sug- gesting that it is an unanticipated off-target that could com- pletely explain the phenotype conferred by the interfering RNA. Perrimon proposed that incorporating other types of data, such as protein-protein interaction information, can help decipher which hits are physiologically relevant. Rene Bernards (Netherlands Cancer Institute, Amsterdam, The Netherlands) commented that reporting lists of unconfirmed hits from genome-wide RNAi screens in humans might be detrimental to future work by creating distractions from more productive lines of research, and that scientists (and journals) perhaps need to be more mindful of this. The boundaries between traditional notions of cellular signal- ing and more genomic and systematic approaches to biology are becoming increasingly blurred, and the recent Keystone conference on signaling networks reflected an expanded view of signaling. It is becoming increasingly accepted that genes, proteins, cells, and organisms function as components of larger systems, rather than independent activities contributing to a single defined outcome, and many presentations at