siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake 英文参考文献.docVIP

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siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake 英文参考文献.doc

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siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake 英文参考文献

Open Access Re rch 2007GalvezetVoal.umesea8, Issue 7, Article R142 siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake Thierry Galvez, Mary N Teruel, Won Do Heo, Joshua T Jones, Man Lyang Kim, Jen Liou, Jason W Myers and Tobias Meyer Address: Department of Chemical and Systems Biology and Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305, USA. Correspondence: Thierry Galvez. Email: galvez@mpi-cbg.de. Tobias Meyer. Email: tobias1@ Published: 19 July 2007 Received: 16 February 2007 Revised: 30 May 2007 Accepted: 19 July 2007 Genome Biology 2007, 8:R142 (doi:10.1186/gb-2007-8-7-r142) The electronic version of this article is the complete one and can be found online at /2007/8/7/R142 ? 2007 Galvez et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Regulators3,p4,5A-tsruisrpvheofyosotransferrinpfh1a,8te0-4mhTuOmuptakeRansigdicer-generatednaling pathwaysignalingas a primsiRNAsary reguusinglator oautomatedf iron-tranquantitativesferrin uptakimaginge./p identified the phosphatidylinositol- Abstract Background: Iron uptake via endocytosis of iron-transferrin-transferrin receptor complexes is a rate-limiting step for cell growth, viability and proliferation in tumor cells as well as non- transformed cells such as activated lymphocytes. Signaling pathways that regulate transferrin uptake have not yet been identified. Results: We surveyed the human signaling proteome for regulators that increase or decrease transferrin uptake by screening 1,804 dicer-generated signaling small interfering RNAs using automated quantitative imaging. In addition to known transport proteins, we id