SLE - Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus 英文参考文献.docVIP

Arthritis Research Therapy Vol 5 No 4 Costenbader and Liang Commentary SLE Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus Karen H Costenbader1,2,3 and Matthew H Liang1,3,4 1The Robert B. Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Brigham and Women’s Hospital, Boston, Massachusetts, USA 2Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA 3Harvard Medical School, Boston, Massachusetts, USA 4Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA Corresponding author: Karen H Costenbader (e-mail: kcostenbader@) Received: 10 Mar 2003 Revisions requested: 4 Apr 2003 Revisions received: 24 Apr 2003 Accepted: 30 Apr 2003 Published: 23 May 2003 Arthritis Res Ther 2003, 5:178-179 (DOI 10.1186/ar773) ? 2003 BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362) Abstract Accelerated atherosclerotic vascular disease (ASVD) is a major cause of death in systemic lupus erythematosus (SLE). Although many authorities are calling for aggressive assessment and management of cardiac risk factors in patients with SLE, both theoretical and practical barriers to this approach exist. It seems that SLE and/or its treatment are themselves strong risk factors for the development of ASVD and it is unclear how much this risk can be decreased by the control of traditional risk factors. Studies from several centers have shown that suboptimal risk factor management and barriers to acceptance of these measures must also be studied further. Keywords: atherosclerosis, cardiac risk factor, coronary artery disease, systemic lupus erythematosus Introduction same risk factors as those observed in normal individuals are also involved. This has motivated authorities in both rheumatology and preventive cardiology to advocate more aggressive risk fa