Sleep Deprivation Impairs Object-Selective Attention A View from the Ventral Visual Cortex 英文参考文献.docVIP

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Sleep Deprivation Impairs Object-Selective Attention A View from the Ventral Visual Cortex 英文参考文献.doc

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Sleep Deprivation Impairs Object-Selective Attention A View from the Ventral Visual Cortex 英文参考文献

SleepDeprivationImpairsObject-SelectiveAttention:A ViewfromtheVentralVisualCortex JulianLim1,2*,JiatChowTan1,SarayuParimal1,DavidF.Dinges2,MichaelW.L.Chee1* 1Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore, 2Division of Sleep and Chronobiology, Department of Psychiatry,UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica Abstract Background: Most prior studies on selective attention in the setting of total sleep deprivation (SD) have focused on behaviororactivationwithinfronto-parietalcognitivecontrolareas.Here,weevaluatedtheeffectsofSDonthetop-down biasing of activation of ventral visual cortex and on functional connectivity between cognitive control and other brain regions. Methodology/Principal Findings: Twenty-three healthy young adult volunteers underwent fMRI after a normal night of sleep(RW)andaftersleepdeprivationinacounterbalancedmannerwhileperformingaselectiveattentiontask.Duringthis task,picturesofhousesorfaceswererandomlyinterleavedamongscrambledimages.Acrossdifferentblocks,volunteers respondedtohousebutnotfacepictures,facebutnothousepictures,orpassivelyviewedpictureswithoutresponding. Theappearanceoftask-relevantpictureswasunpredictableinthisparadigm.SDresultedinlessaccuratedetectionoftarget pictures without affecting the mean false alarm rate or response time. In addition to a reduction of fronto-parietal activation, attending to houses strongly modulated parahippocampal place area (PPA) activation during RW, but this attention-drivenbiasingofPPAactivationwasabolishedfollowingSD.Additionally,SDresultedinasignificantdecrement infunctionalconnectivitybetweenthePPAandtwocognitivecontrolareas,theleftintraparietalsulcusandtheleftinferior frontallobe. Conclusions/Significance: SD impairs selective attention as evidenced by reduced selectivity in PPA activation. Further, reduction in fronto-parietal and ventral visual task-related activation suggests that it also affec