Sleep quality in mechanically ventilated patients comparison between NAVA and PSV modes 英文参考文献.docVIP
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Sleep quality in mechanically ventilated patients comparison between NAVA and PSV modes 英文参考文献
Delisleetal.AnnalsofIntensiveCare2011,1:42
/content/1/1/42
RESEARCH
OpenAccess
Sleepqualityinmechanicallyventilatedpatients:
comparisonbetweenNAVAandPSVmodes
StéphaneDelisle1,2,3*,PaulOuellet3,4,5,PatrickBellemare1,Jean-PierreTétrault3andPierreArsenault3
Abstract
Background:Mechanicalventilationseemstooccupyamajorsourceinalterationinthequalityandquantityof
sleepamongpatientsinintensivecare.Qualityofsleepisnegativelyaffectedwithfrequentpatient-ventilator
asynchroniesandmorespecificallywithmodesofventilation.Thequalityofsleepamongventilatedpatients
seemstoberelatedinparttothealterationbetweenthecapacitiesoftheventilatortomeetpatientdemand.The
objectiveofthisstudywastocomparetheimpactoftwomodesofventilationandpatient-ventilatorinteraction
onsleeparchitecture.
Methods:Prospective,comparativecrossoverstudyin14conscious,nonsedated,mechanicallyventilatedadults,
duringweaninginauniversityhospitalmedicalintensivecareunit.Patientsweresuccessivelyventilatedina
randomorderedcross-oversequencewithneurallyadjustedventilatoryassist(NAVA)andpressuresupport
ventilation(PSV).Sleeppolysomnographywasperformedduringfour4-hourperiods,twowitheachmodein
randomorder.
Results:Thetracingsoftheflow,airwaypressure,andelectricalactivityofthediaphragmwereusedtodiagnose
centralapneasandineffectiveefforts.Themainabnormalitieswerealowpercentageofrapideyemovement
(REM)sleep,foramedian(25th-75thpercentiles)of11.5%(range,8-20%)oftotalsleep,andahighlyfragmented
sleepwith25arousalsandawakeningsperhourofsleep.ProportionsofREMsleepdurationweredifferentinthe
twoventilatorymodes(4.5%(range,3-11%)inPSVand16.5%(range,13-29%)duringNAVA(p=0.001)),aswellas
thefragmentationindex,with40±20arousalsandawakeningsperhourinPSVand16±9duringNAVA(p=
0.001).Therewerelargedifferencesinineffectiveefforts(24±23perhourofsleepinPSV,and0duringNAVA)
andepisodesofcentralapnea(10.5±11inPSVvs.0duringNAVA).Minuteventilationwassimilarinbothmodes.
Conclusions:NAVAimprovesthequalityofsleepoverPSVintermsofREMsleep,fragmentationindex,and
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