Skeletal Muscle Phosphodiester Content Relates to Body Mass and Glycemic Control 英文参考文献.docVIP

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Skeletal Muscle Phosphodiester Content Relates to Body Mass and Glycemic Control 英文参考文献.doc

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Skeletal Muscle Phosphodiester Content Relates to Body Mass and Glycemic Control 英文参考文献

SkeletalMusclePhosphodiesterContentRelatestoBody MassandGlycemicControl JuliaSzendroedi1,2,3,AlbrechtIngoSchmid3,4,MarekChmelik3,4,MartinKrssak5,6,PeterNowotny1,6 ThomasPrikoszovich6,AlexandraKautzky-Willer6,MichaelWolzt6,WernerWaldha¨usl6 ,Michael , Roden1,2,3 * 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich-Heine University Du¨sseldorf, Du¨sseldorf, Germany, 2DepartmentofMetabolicDiseases,Heinrich-HeineUniversityDu¨sseldorf,Du¨sseldorf,Germany,3Karl-LandsteinerInstituteforEndocrinologyandMetabolism,Medical UniversityofVienna,Vienna,Austria,4MRCenterofExcellence,MedicalUniversityofVienna,Vienna,Austria,5DepartmentofRadiology,MedicalUniversityofVienna, Vienna,Austria,6DepartmentofInternalMedicine3,MedicalUniversityofVienna,Vienna,Austria Abstract Background: Aging and insulin resistance have been related to reduced mitochondrial function and oxidative stress. Muscular phosphodiesters (PDE) are comprised of metabolites of phospholipid breakdown and may reflect membrane damage.WeaimedtotestthehypothesisthatmyocellularPDEareincreasedinpatientswithtype2diabetes(T2D)and correlateinverselywithmitochondrialATPturnover. Methods: A Cross-sectional study in the Clinical Research Facility of an University hospital was performed. 10 nonobese middle-agedpatientswithT2D,10healthyhumansmatchedforsex,ageandphysicalactivityindex(CONm)and18young healthyhumans(CONy)wereincluded.MyocellularPDEandunidirectionalfluxthroughATPsynthase(fATP)weremeasured with 31Pmagneticresonancespectroscopy (MRS).Intramyocellular(IMCL)andhepatocellularlipiddeposition(HCL)were quantifiedwith 1HMRS.Insulinsensitivity(Rd)wasassessedfromhyperinsulinemic-euglycemicclamptestsin10T2D,10 CONmand11CONy. Results:Duringfasting,T2DandCONmhad1.5foldgreaterPDEthanCONy(2.860.2,2.560.2,1.760.1mmol/l,P=0.004). StimulationbyinsulindidnotaffectPDEinanygroup.PDEcorrelatednegativelywithRd(r=20.552,p,0.005)andfATP (r=20.396, p,0.05) and positively with age (r=0.656