Situs inversus totalis and secondary biliary cirrhosis a case report 英文参考文献.docVIP

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Situs inversus totalis and secondary biliary cirrhosis a case report 英文参考文献.doc

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Situs inversus totalis and secondary biliary cirrhosis a case report 英文参考文献

S?kmenetal.ComparativeHepatology2011,10:5 /content/10/1/5 CASE REPORT OpenAccess Situsinversustotalisandsecondarybiliary cirrhosis:acasereport Hac?MehmetS?kmen1,Kamil?zdil1,Turan?alhan1*,Abdurrahman?ahin1,Ebubekir?enate?2,ResulKahraman1, AdilNi?delio?lu1andEbruZemheri3 Abstract Situsinversustotalisisisacongenitalanomalyassociatedwithvariousvisceralabnormalities,butthereisnodata abouttherelationshipbetweensecondarybiliarycirrhosisandthatcondition.Weherepresentacaseofa58year- oldfemalewithsitusinversustotaliswhowasadmittedtoourclinicwithextrahepaticcholestasis.Afterexcluding allpotentialcausesofbiliarycirrhosis,secondarybiliarycirrhosiswasdiagnosedbasedonthepatient’ shistory, imagingtechniques,clinicalandlaboratoryfindings,besideshistolopathologicalfindings.Aftertreatmentwith tauroursodeoxycholicacid,allbiochemicalparameters,includingtotal/directbilirubin,alanineaminotransferase, aspartateaminotransferase,alkalinephosphataseandgamaglutamyltransferase,returnedtonormalrangesatthe secondmonthofthetreatment.Wethinkthatthisisthefirstcaseinliteraturethatmayindicatethedevelopment ofsecondarybiliarycirrhosisinapatientwithsitusinversustotalis.Inconclusion,situsinversusshouldbe consideredasararecauseofbiliarycirrhosisinpatientswithsitusinversustotaliswhichispresentedwith extrahepaticcholestasis. Keywords:Situsinversustotalis,secondarybiliarycirrhosis,tauroursodeoxycholicacid Background Situsinversustotalis(SIT)isacongenitalanomalychar- SBC who referred to our clinic due to extrahepatic cholestasis. acterized by complete transposition of abdominal and thoracicorgans.Asabirthdefectinnewborninfants,it Casepresentation hasanestimatedincidenceof1/15000to10000casesin A58-year-oldfemalepatient,whocomplainedoficterus live births, with a male/female ratio of 3:2. Generally, appearing inthelast6-7months, alongwiththesymp- thisrareanomalyisdiagnosedincidentallyduringthor- toms offatigue and loss ofappetite continued for 2-3 acicandabdominalimaging.Thecauseofsitusinvers