Six Types of Multistability in a Neuronal Model Based on Slow Calcium Current 英文参考文献.docVIP

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Six Types of Multistability in a Neuronal Model Based on Slow Calcium Current 英文参考文献.doc

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Six Types of Multistability in a Neuronal Model Based on Slow Calcium Current 英文参考文献

SixTypesofMultistabilityinaNeuronalModelBasedon SlowCalciumCurrent TatianaMalashchenko1,AndreyShilnikov2,3,GennadyCymbalyuk1,2 * 1Department of Physics and Astronomy, Georgia State University, Atlanta, Georgia, United States of America, 2The Neuroscience Institute, Georgia State University, Atlanta,Georgia,UnitedStatesofAmerica,3DepartmentofMathematicsandStatistics,GeorgiaStateUniversity,Atlanta,Georgia,UnitedStatesofAmerica Abstract Background: Multistability of oscillatory and silent regimes is a ubiquitous phenomenon exhibited by excitable systems suchasneuronsandcardiaccells.Multistabilitycanplayfunctionalrolesinshort-termmemoryandmaintainingposture.It seems to pose an evolutionary advantage for neurons which are part of multifunctional Central Pattern Generators to possessmultistability.Themechanismssupportingmultistabilityofburstingregimesarenotwellunderstoodorclassified. Methodology/PrincipalFindings:Ourstudyisfocusedondeterminingthebio-physicalmechanismsunderlyingdifferent typesofco-existenceoftheoscillatoryandsilentregimesobservedinaneuronalmodel.Wedevelopalow-dimensional modeltypifyingthedynamicsofasingleleechheartinterneuron.Wecarryoutabifurcationanalysisofthemodelandshow thatitpossessessixdifferenttypesofmultistabilityofdynamicalregimes.Thesetypesaretheco-existenceof1)bursting and silence, 2) tonic spiking and silence, 3) tonic spiking and subthreshold oscillations, 4) bursting and subthreshold oscillations, 5) bursting, subthreshold oscillations and silence, and 6) bursting and tonic spiking. Thesefirst five types of multistabilityoccurduetothepresenceofaseparatingregimethatiseitherasaddleperiodicorbitorasaddleequilibrium. We found that the parameter range wherein multistability is observed is limited by the parameter values at which the separatingregimesemergeandterminate. Conclusions:Wedevelopedaneuronalmodelwhichexhibitsarichvarietyofdifferenttypesofmultistability.Wedescribed anovelmechanismsupportingthebistabilityofburstingandsilence.Thisneuronalm