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Site-SpecificRiskFactorsforColorectalCancerina
KoreanPopulation
AesunShin1,JungnamJoo2,JeonginBak2,Hye-RyungYang2,JeongseonKim1,SoheePark2,
Byung-HoNam2*
1CancerEpidemiologyBranch,NationalCancerCenter,Goyang-si,RepublicofKorea,2CancerBiostatisticsBranch,NationalCancerCenter,Goyang-si,RepublicofKorea
Abstract
Weinvestigatedtheassociationofcolorectalcancerriskfactorswithdifferentcolorectalcancersubsitestoassessetiological
differencesforcancersoftheproximalcolon,distalcolon,andrectum.Includedinthisstudywere869,725menand395,501
womenwhoparticipatedinahealthexaminationprovidedbytheKoreanNationalHealthSystembetween1996and1997.
During up to 7 years of follow-up, 4,144 incident colorectal cancer cases were detected (3,051 men and 1,093 women).
Greaterheightwasassociatedwithelevatedriskfordistalcoloncancerandrectalcancerinbothmenandwomen.Family
historyofcancerwasassociatedwithhigherriskforcancersoftheproximalcoloninmenanddistalcoloninbothmenand
women. Frequent alcohol consumption and consuming high amounts of alcohol were associated with elevated risk for
distalcoloncancerinmenandhigherriskforrectalcancerinwomen.Frequentmeatconsumptionwasassociatedwithrisk
forproximalcoloncancerinmenandforrectalcancerinwomen.Ourfindingssuggestthatriskfactorsforcolorectalcancer
aredifferentbysubsitesofcolonandrectum,aswellasbysex.
Citation: Shin A, Joo J, Bak J, Yang H-R, Kim J, et al. (2011) Site-Specific Risk Factors for Colorectal Cancer in a Korean Population. PLoS ONE 6(8): e23196.
doi:10.1371/journal.pone.0023196
Editor:Pan-ChyrYang,NationalTaiwanUniversityHosipital,Taiwan
ReceivedMay3,2011;AcceptedJuly8,2011;PublishedAugust10,2011
Copyright:?2011Shinetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted
use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThisworkwassupportedbytheNationalCancerCenter,Korea(grantNo.0810190-3).Thefundershadnoroleinstudydesign,datacollectionand
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