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Skin prick testing in patients using beta-blockers a retrospective analysis 英文参考文献
FungandKimAllergy,Asthma ClinicalImmunology2010,6:2
/content/6/1/2
ALLERGY, ASTHMA CLINICAL
IMMUNOLOGY
RESEARCH
OpenAccess
Skinpricktestinginpatientsusingbeta-blockers:
aretrospectiveanalysis
IreneNFung1,HaroldLKim1,2*
Abstract
Rationale:Theuseofbeta-blockersisarelativecontraindicationinallergenskintestingyetthereisapaucityof
literatureonadverseeventsinthiscircumstance.Weexaminedapopulationofskintestedpatientsonbeta-
blockerstolookforanyadverseeffects.
Methods:Chartsfrom2004-2008inasingleallergyclinicwerereviewedforanypatientstakingabeta-blocker
whenskintested.Datawasexaminedforskintestreactivity,typeofskintest,concomitantasthmadiagnosis,
allergenstested,andadverseevents.
Results:Onehundredandninety-onepatientsweretakingbeta-blockerswhenskintestingoccurred.Seventy-two
patientshadpositiveskintests.Notestsresultedinanadverseevent.
Conclusions:Thisdatademonstratestherelativesafetyofadministratingofskinprickteststopatientsonbeta-
blockertreatment.Largerprospectivestudiesareneededtosubstantiatethefindingsofthisstudy.
Introduction
for IgE-mediated disease cannot stop treatment with a
Betaantagonists,commonlyknownasbeta-blockers,are beta-blocking agent [12].” However, in our literature
acommonlyprescribedclassofmedications.Beta-block- reviewonthetopic,nocasereportsorprospectivestu-
ersareusedinthetreatmentofcongestiveheartfailure, dies report adverse events in patients on beta-blockers
coronaryheartdisease,cardiacarrhythmia,hypertension, who underwent skin testing. This retrospective study
tremor,glaucoma,andmigraineheadache.Importantly, investigates whether there is any increased risk of ana-
beta-blockers significantly reduce both morbidity and phylaxis in patients who were allergy skin tested while
mortalityratesincongestiveheartfailure, inacutecor- theycontinuedonabeta-blockermedication.
onary syndrome, and post myocardial infarction [1-3].
However,beta-blockademayplaceatopicsubjectsatan
Methods
increased riskofananaphylactic reacti
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