Sleep-Disordered Breathing and Mortality A Prospective Cohort Study 英文参考文献.docVIP

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Sleep-Disordered Breathing and Mortality A Prospective Cohort Study 英文参考文献.doc

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Sleep-Disordered Breathing and Mortality A Prospective Cohort Study 英文参考文献

Sleep-DisorderedBreathingandMortality:AProspective CohortStudy NareshM.Punjabi1*,BrianS.Caffo1,JamesL.Goodwin2,DanielJ.Gottlieb3,AnneB.Newman4,GeorgeT. O’Connor5,DavidM.Rapoport6,SusanRedline7,HelaineE.Resnick8,JohnA.Robbins9,EyalShahar2, MarkL.Unruh4,JonathanM.Samet10 1JohnsHopkinsUniversity,Baltimore,Maryland,UnitedStatesofAmerica,2UniversityofArizona,Tucson,Arizona,UnitedStatesofAmerica,3VABostonHealthcare System,Boston,Massachusetts,UnitedStatesofAmerica, 4UniversityofPittsburgh,Pittsburgh,Pennsylvania, UnitedStatesofAmerica, 5BostonUniversitySchoolof Medicine,Boston,Massachusetts,UnitedStatesofAmerica,6NewYorkUniversitySchoolofMedicine,NewYork,NewYork,UnitedStatesofAmerica,7CaseWestern ReserveUniversity,Cleveland,Ohio,UnitedStatesofAmerica,8AmericanAssociationofHomesandServicesfortheAging,Washington,D.C.,UnitedStatesofAmerica, 9UniversityofCalifornia,Davis,California,UnitedStatesofAmerica,10UniversityofSouthernCalifornia,LosAngeles,California,UnitedStatesofAmerica Abstract Background: Sleep-disordered breathing is a common condition associated with adverse health outcomes including hypertension and cardiovascular disease. The overall objective of this study was to determine whether sleep-disordered breathinganditssequelaeofintermittenthypoxemiaandrecurrentarousalsareassociatedwithmortalityinacommunity sampleofadultsaged40yearsorolder. MethodsandFindings:Weprospectivelyexaminedwhethersleep-disorderedbreathingwasassociatedwithanincreased risk of death from any cause in 6,441 men and women participating in the Sleep Heart Health Study. Sleep-disordered breathingwasassessedwiththeapnea–hypopneaindex(AHI)basedonanin-homepolysomnogram.Survivalanalysisand proportionalhazardsregressionmodelswereusedtocalculatehazardratiosformortalityafteradjustingforage,sex,race, smokingstatus,bodymassindex,andprevalentmedicalconditions.Theaveragefollow-upperiodforthecohortwas8.2y duringwhich1,047participants(587menand460women)died.Comparedtothosewithoutsleep-disorderedbreathi