Sleep Deprivation Impairs Consolidation of Cued Fear Memory in Rats 英文参考文献.docVIP

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Sleep Deprivation Impairs Consolidation of Cued Fear Memory in Rats 英文参考文献.doc

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Sleep Deprivation Impairs Consolidation of Cued Fear Memory in Rats 英文参考文献

SleepDeprivationImpairsConsolidationofCuedFear MemoryinRats TankeshKumar,SushilK.Jha* SchoolofLifeSciences,JawaharlalNehruUniversity,NewDelhi,India Abstract Post-learningsleepfacilitatesnegativememoryconsolidationandalsohelpspreserveitoverseveralyears.Itisbelieved, therefore,thatsleepdeprivationmayhelppreventconsolidationoffearfulmemory.Itseffect,however,onconsolidationof negative/frightening memories is not known. Cued fear-conditioning (CuFC) is a widely used model to understand the neuralbasisofnegativememoryassociatedwithanxietydisorders.Inthisstudy,wefirstdeterminedthesuitablecircadian timingforconsolidationofCuFCmemoryandchangesinsleeparchitectureafterCuFC.Thereafter,westudiedtheeffectof sleepdeprivationonCuFCmemoryconsolidation.ThreesetsofexperimentswereperformedinmaleWistarrat(n=51).In experiment-I,animalswereconditionedtocued-fearbypresentingtentone-shockpairedstimuliduringlights-on(7AM) (n=9)andlights-off(7PM)(n=9)periods.Inexperiment-II,animalswerepreparedforpolysomnographicrecording(n=8) andchangesinsleeparchitectureafterCuFCwasdetermined.Furtherinexperiment-III,animalswerecuedfear-conditioned duringthelights-offperiodandwererandomlydividedintofourgroups:Sleep-Deprived(SD)(n=9),Non-SleepDeprived (NSD)(n=9),StressControl(SC)(n=9)andToneControl(n=7).Percentfreezingamount,ahallmarkoffear,wascompared statistically in these groups. Rats trained during the lights-off period exhibited significantly more freezing compared to lights-onperiod.InCuFCtrainedanimals,totalsleepamountdidnotchange,however,REMsleepdecreasedsignificantly. Further,outoftotalsleeptime,animalsspentproportionatelymoretimeinNREMsleep.Nevertheless,SDanimalsexhibited significantlylessfreezingcomparedtoNSDandSCgroups.Thesedatasuggestthatsleepplaysanimportantroleinthe consolidationofcuedfear-conditionedmemory. Citation: Kumar T, Jha SK (2012) Sleep Deprivation Impairs Consolidation of Cued Fear Memory in Rats. PLoS ONE 7(10): e47042. doi:10.1371/ journal.pone.0047042 Editor:AnthonyE.Kline,Univ