Small genomes and big science 英文参考文献.docVIP

Meeting report Small genomes and big science Jeremy Edwards Address: Molecular Genetics and Microbiology, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, and Chemical and Nuclear Engineering, University of New Mexico, Albuquerque, NM 87131, USA. Email: jsedwards@ Published: 13 March 2006 Genome Biology 2006, 7:308 (doi:10.1186/gb-2006-7-3-308) The electronic version of this article is the complete one and can be found online at /2006/7/3/308 ? 2006 BioMed Central Ltd sequenced 60 Mb from the uranium-contaminated soil A report of the 13th Annual International Conference on samples and identified a composite sequence of approxi- Microbial Genomes, Madison, USA, 11-15 September 2005. mately 6 Mb in 879 contigs. They were unable to determine exactly how many species made up the community, but they did identify Azoarcus species (at least four) as well as other The presentations from the 2005 Annual Conference on Microbial Genomes focused on diverse areas of microbial genomics - from the evolution of enterobacteria to structural genomics and systems biology. An overriding theme of the meeting was the importance of new technologies and tools for functional genomics and how they are being used to understand microbial physiology. This meeting took a big step forward in showing how to take advantage of the increasing availability of microbial genomes to fill in the gap between functional genomics and physiology. This report discusses a few of the many highlights of the meeting in the fields of metagenomics, structural genomics, new genomics technologies and systems biology. bacterial species via analysis of 16S rDNA. This type of metagenomic analysis promises to provide a critical insight into the biology of microbes in their natural environment, but the amount of the sequences that need to be analyzed begs for n