Sorafenib increases 18-FDG colic uptake demonstration in patients with differentiated thyroid cancer 英文参考文献.docVIP

Ciappuccinietal.EJNMMIResearch2012,2:18 /content/2/1/18 SHORT COMMUNICATION OpenAccess Sorafenibincreases18-FDGcolicuptake: demonstrationinpatientswithdifferentiated thyroidcancer RenaudCiappuccini1*,GéraldineTrzepla2,NatachaHeutte3,EmmanuelSevin4, MariePierreGalais4andStéphaneBardet1 Abstract Background:Toassess18-fluorodeoxyglucose(FDG)boweluptakeinpatientswithdifferentiatedthyroidcancer (DTC)treatedwithsorafenib. Findings:Visual(5-pointscale)andhighmaximumstandarduptakevalue(SUVmax)semi-quantitativeanalyses wereconductedin63positronemissiontomography(PET)studiesperformedinpatientsonsorafenib(group1, n=20),inacontrolgroup(group2,n=28)andinpatientsonsunitiniborvandetanib(group3,n =15). Moderateorhighanddiffuseboweluptake(grade4or5)wasobservedin90%ofthePETscansofgroup1versus noneingroup2.Only20%ofPETscansingroup3werescoredgrade4.SUVmaxvaluesweresignificantlyhigher forallcolicsegmentsingroup1thaningroup2(P0.0001)or3(P0.0004).Thisuptakepatternappearedrapidly (onemonth)anddisappearedaftersorafenibwithdrawal. Conclusions:FDGuptakeisincreasedinthecolonofDTCpatientstreatedbysorafenib. Keywords:Sorafenib,FDGPET,Thyroidcancer,Colicuptake Findings Background patients treated by other TKI such as sunitinib and vandetanib. Sorafenibisanewtargetedtherapywithanangiogenesis inhibitingactivity,belongingtothetyrosinekinaseinhi- bitors (TKI) family [1]. This multikinase inhibitor has beenevaluatedinvariouscancerswithpromisingresults [2-4], including in medullary [5] and in differentiated thyroid cancer (DTC) [6,7]. In the first patients with DTC treated by sorafenib in our unit, we often noticed anintenseanddiffuse18-Fluorodeoxyglucose(FDG)up- takeintheabdomen.Theaimofthepresentretrospect- ive work was to assess the proportion of patients with such an uptake, to determine the uptake pattern in the small intestine and in the colon, to evaluate the scinti- graphic outcome pattern after sorafenib withdrawal when possible and to compare this uptake with that of Methods Patients Betwe