Statistical validation of the criteria for symptom remission in schizophrenia Preliminary findings 英文参考文献.docVIP

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Statistical validation of the criteria for symptom remission in schizophrenia Preliminary findings 英文参考文献.doc

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Statistical validation of the criteria for symptom remission in schizophrenia Preliminary findings 英文参考文献

BMC Psychiatry BioMedCentral Research article Open Access Statistical validation of the criteria for symptom remission in schizophrenia: Preliminary findings Mark GA Opler*1,4, Lawrence H Yang1,4, Sue Caleo2 and Philip Alberti3,4 Address: 1Columbia University, Department of Psychiatry, New York, NY, USA, 2Health Economics, Janssen Pharmaceutica N.V., Belgium, 3Columbia University, Department of Epidemiology, New York, NY, USA and 4The PANSS Institute, New York, NY USA Email: Mark GA Opler* - mark.opler@; Lawrence H Yang - lyang@; Sue Caleo - SCALEO1@PSMBE.JNJ.COM; Philip Alberti - philipalberti@ * Corresponding author Published: 24 July 2007 Received: 5 February 2007 Accepted: 24 July 2007 BMC Psychiatry 2007, 7:35 doi:10.1186/1471-244X-7-35 This article is available from: /1471-244X/7/35 ? 2007 Opler et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Published methods for assessing remission in schizophrenia are variable and none have been definitively validated or standardized. Andreasen et al (2005) suggest systematic operational criteria using eight PANSS items for which patients must score ≤ 3 (mild) for at least six months. Methods: Using data from a one year, multi-site clinical trial (n = 675) remission criteria were compared to total PANSS scores and other endpoints and demonstrate excellent agreement with overall clinical status. Results: Compared to total PANSS score of 60 points and other criteria, at time points 6 months (8 and 12 months) the specificity of the remission criteria was 85%, i.e. of the patients who had a total score 60, 85% were classified as not in remission. Sensitivity was also very high; 75% of patients with scores of 60 were