Time- and exercise-dependent gene regulation in human skeletal muscle 英文参考文献.docVIP

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Time- and exercise-dependent gene regulation in human skeletal muscle 英文参考文献.doc

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Time- and exercise-dependent gene regulation in human skeletal muscle 英文参考文献

Open Access Re rch 2003ZambonetVoal.lumesea4, Issue 10, Article R61 Time- and exercise-dependent gene regulation in human skeletal muscle Alexander C Zambon*, Erin L McDearmon?, Nathan Salomonis*, Karen M Vranizan*§, Kirsten L Johansen?, Deborah Adey?, Joseph S Takahashi?, Morris Schambelan? and Bruce R Conklin*? Addresses: *Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94141, USA. ?Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA. ?Department of Medicine, University of California, San Francisco, CA 94141, USA. §Functional Genomics Lab, University of California, Berkekley, CA 94720, USA. Correspondence: Bruce R Conklin. E-mail: bconklin@ Published: 25 September 2003 Received: 20 June 2003 Revised: 12 August 2003 Accepted: 18 August 2003 Genome Biology 2003, 4:R61 The electronic version of this article is the complete one and can be found online at /2003/4/10/R61 ? 2003 Zambon et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Time-cShrehkogaeuunlrelsgateatandhisloaminntuaoexercise-dependentmsrfceuklmesecyraleegimneatnnoaedisne.claidnnbgiynisadaucgeneoccerieptichcregulationlaolsceckosmmheipfctohsnaiinennichumanstimrocf.aBadnoiatohskeletalnrgerxahnyrticshimmsmuscleeass-,infresponselduucctuedatrioemtonsoenvironmentalideplihnygsaionldogcyircaachanges.nddiabnehrhavyiExercisetohrmwsirthelyacausesopnertihoedstructuraltofranaroundscriptio24nal Abstract Background: Skeletal muscle remodeling is a critical component of an organisms response to environmental changes. Exercise causes structural changes in muscle and can induce phase shifts in circadian rhythms, fluctuations in physiology and behavior with a period of around 24 hou