Tracheotomy does not affect reducing sedation requirements of patients in intensive care – a retrospective study 英文参考文献.docVIP

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Tracheotomy does not affect reducing sedation requirements of patients in intensive care – a retrospective study 英文参考文献.doc

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Tracheotomy does not affect reducing sedation requirements of patients in intensive care – a retrospective study 英文参考文献

Available online /content/10/4/R99 Research Open Access Vol 10 No 4 Tracheotomy does not affect reducing sedation requirements of patients in intensive care – a retrospective study Denise P Veelo1,2, Dave A Dongelmans1, Jan M Binnekade1, Johanna C Korevaar3, Margreeth B Vroom1 and Marcus J Schultz1,4 1Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands 2Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands 3Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands 4Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Corresponding author: Marcus J Schultz, m.j.schultz@amc.uva.nl Received: 31 Jan 2006 Revisions requested: 3 Mar 2006 Revisions received: 23 May 2006 Accepted: 6 Jun 2006 Published: 10 Jul 2006 Critical Care 2006, 10:R99 (doi:10.1186/cc4961) This article is online at: /content/10/4/R99 ? 2006 Veelo et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Translaryngeal intubated and ventilated patients often need sedation to treat anxiety, agitation and/or pain. However, when we focused on a shorter time interval (two days before and after tracheotomy), there were no differences in prescribed doses of morphine and midazolam. Studying the course in DD/MDD from seven days before the placement of tracheotomy, we found a significant decline in dosage. From day -7 to day -1, morphine dosage (DD/MDD) dec