Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases 英文参考文献.docVIP

Arthritis Research Therapy Vol 7 No 2 Wahl and Chen Review Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases Sharon M Wahl1 and Wanjun Chen2 1Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA 2Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA Corresponding author: Sharon M Wahl, smwahl@ Published: 24 January 2005 Arthritis Res Ther 2005, 7:62-68 (DOI 10.1186/ar1504) ? 2005 BioMed Central Ltd Abstract and prevention of the onset of autoimmune disease. Their existence is no longer in question, but true to their history these cells, their origin, generation, and mechanisms of Naturally occurring CD4+CD25+ regulatory T cells mediate immune suppression to limit immunopathogenesis associated with chronic inflammation, persistent infections and autoimmune diseases. Their mode of suppression is contact-dependent, antigen-nonspecific and involves a nonredundant contribution from the cytokine transforming growth factor (TGF)-β. Not only can TGF-β mediate cell–cell suppression between the regulatory T cells and CD4+CD25– or CD8+ T cells, but new evidence also reveals its role in the conversion of CD4+CD25– T cells, together with TCR antigen stimulation, action have generated considerable controversy. Recognition of the potential impact of these cells in clinical cellular therapy has driven a rapid expansion of the field in order to understand and manipulate the regulatory T cell population to devise strategies to control auto- immunity, transplantation tolerance, tumor immunity, into the regulatory phenotype. Elemental to this allergy and infectious diseases, particularly