Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure 英文参考文献.docVIP

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Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure 英文参考文献.doc

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Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure 英文参考文献

BMC Physiology BioMedCentral Research article Open Access Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure Cristi L Galindo1, Michael A Skinner2, Mounir Errami1, L Danielle Olson1, David A Watson1, Jing Li1, John F McCormick1, Lauren J McIver1, Neil M Kumar1, Thinh Q Pham1 and Harold R Garner*1 Address: 1McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA and 2Department of Surgery, University of Texas Southwestern Medical Center and Childrens Medical Center of Dallas, Texas, USA Email: Cristi L Galindo - galindo@; Michael A Skinner - MICHAEL.SKINNER@; Mounir Errami - Mounir.Errami@UTS; L Danielle Olson - danielleolson@; David A Watson - davidawatson09@; Jing Li - crastalli@; John F McCormick - john.mccormick@; Lauren J McIver - Lauren.McIver@UTS; Neil M Kumar - nmk2008@; Thinh Q Pham - thinhsypham@; Harold R Garner* - harold.garner@ * Corresponding author Published: 9 December 2009 Received: 16 April 2009 Accepted: 9 December 2009 BMC Physiology 2009, 9:23 doi:10.1186/1472-6793-9-23 This article is available from: /1472-6793/9/23 ? 2009 Galindo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Isoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease. In this study, we compared the transcriptional response of the heart in this model to other animal models of heart failure, as well as to the transcriptional response of human hearts suffering heart failure. Results: We performed microarray analyses on RNA from mice with isoproterenol-induced cardiac hypertroph