Tribenzamidomethyl Hydrazine 英文参考文献.docVIP

Molbank 2010, M710; doi:10.3390/M710 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note Tribenzamidomethyl Hydrazine Jasmina Tanatarec 1, Bozhana Mikova 2, Gerald Draeger 3 and Emil Popovski 1,* 1 Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Arhimedova 5, PO Box 162, 1000 Skopje, Macedonia 2 Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Akad.G.Bonchev Str. Bl.9, Sofia 1113, Bulgaria 3 Institute of Organic Chemistry, Leibniz University of Hannover, D-30167, Hannover, Germany * Author to whom correspondence should be addressed; E-Mail: popovski.emil@. Received: 26 October 2010 / Accepted: 6 December 2010 / Published: 7 December 2010 Abstract: A new tribenzamidomethyl hydrazine was synthesized and its IR, 1H NMR, 13C NMR and MS spectroscopic data are presented. Keywords: benzamidomethylation; hydrazine; prodrug Many hydrazine derivatives are known to exhibit significant biological activity and several compounds with hydrazine moiety were shown to be effective for treatment of tuberculosis, Parkinson’s disease and hypertension [1]. There is evidence that some hydrazines displaying neuroprotective properties can be used as antidepressant drugs [2], while for some trisubstituted hydrazines antimicrobial effect was observed [3]. The hydrazine moiety has been used for modification of peptides as well. For example, novel building blocks for peptide modification have been designed and synthesized to obtain β-sheet tripeptide mimics that comprise the azapeptide modification at one end [4]. Azapeptides, hydrazine-based peptidomimetics, were found to be potent agents against hepatitis [5], AIDS [6] and SARS [7]. In addition, hydrazine derivatives have been used for derivatization of nanostructures [8]. Therefore, the synthesis of hydra