Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba 英文参考文献.docVIP

Molecules 2011, 16, 4642-4651; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba Hai-Xue Kuang *, Hong-Wei Li, Qiu-Hong Wang, Bing-You Yang, Zhi-Bin Wang and Yong-Gang Xia Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China * Author to whom correspondence should be addressed; E-Mail: hxkuang@; Tel.: +86-451 Fax: +86-451 Received: 15 April 2011; in revised form: 26 May 2011 / Accepted: 27 May 2011 / Published: 3 June 2011 Abstract: The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new β-D-gluco-pyranosyl ester (1) triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid and β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC50 values in the 0.62-3.62 mM range. Keywords: Sanguisorba tenuifolia var. Alba; triterpenoids; α-glucosidase inhibitory activity; diabetes mellitus 1. Introduction Diabetes mellitus (DM), considered a lifestyle related diseases, is a metabolic disease with hyper-glycemia as a symptom and causes many complications [1]. Recently, DM is becoming a serious problem around the World, and according to World Health Organization, it affects approximately 171 million people worldwide and the number is expected to reach to 366 million over the next 20 years [2]. Many researchers have enthusiastically studied the development of antidiabetic  Molecules 2011, 16 464