Two New Compounds Isolated from Liriope muscari 英文参考文献.docVIP

Molecules 2012, 17, 8773-8781; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two New Compounds Isolated from Liriope muscari Wen-Jie Li 1,?, Zhi-Hao Zhang 1,2,?, Xian-Long Cheng 1, Jing Liu 1, Yi He 1, Chao Zhou 1,3, Ying Guo 1, Rui-Chao Lin 1,2,* and Gang-Li Wang 1,* 1 National Institutes for Food and Drug Control, Beijing 100050, China; E-Mails: lwj115@163.com (W.-J.L.); zzh-198518@163.com (Z.-H.Z.) 2 Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China 3 QiQiHaEr Institute for Food and Drug Control, QiQiHaEr 161000, China ? These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: Linrch307@ (R.-C.L.); duneer@163.com (G.-L.W.); Tel.: +86-10-6709-5307 (R.-C.L.); Fax: +86-10-6702-3650 (R.-C.L.). Received: 24 May 2012; in revised form: 15 June 2012 / Accepted: 18 June 2012 / Published: 25 July 2012 Abstract: Two new compounds, (2S,3R)-methyl 7-hydroxy-2-(4-hydroxy-3-methoxy- phenyl)-3-(hydroxymethyl)-2,3-dihydrobenzofuran-5-carboxylate (1) and (4R,5S)-5-(3- hydroxy-2,6-dimethylphenyl)-4-isopropyldihydrofuran-2-one (2), tentatively named norcurlignan and limlactone, respectively, were isolated from Liriope muscari, together with the known compound (?)-pinoresinol (3). The structures of these compounds were elucidated and characterized on the basis of 1D NMR, 2D NMR, CD and MS data. The in vitro antioxidant activities of compounds 1–3 were assessed by the DPPH and ABTS scavenging methods. Keywords: liliaceae; Liriope muscari; norcurlignan; limlactone; antioxidant activity 1. Introduction Liriope muscari (Decne.) Bailey (Liliaceae) is called duantingshanmaidong in China. Due to the lack of Radix Ophiopogonis (maidong in Chinese) resources and the similar pharmacological activities of these two herbal medicines, L. muscari is used locally in Fujian province as