Two New Aryltetralin Lignans from the Roots of Dolomiaea souliei 英文参考文献.docVIP

Molecules 2012, 17, 5544-5549; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two New Aryltetralin Lignans from the Roots of Dolomiaea souliei Hua Wei 1,2, Chunnian He 1,2, Yong Peng 1,2, Sen Zhang 3, Xiaoguang Chen 3 and Peigen Xiao 1,2,* 1 Institute of Medicinal Plant Development, Chinese Academy of Medical Science Peking Union Medical College, Beijing 100193, China 2 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Peking Union Medical College, Beijing 100193, China 3 Institute of Materia Medica, Chinese Academy of Medical Science Peking Union Medical College, Beijing 100193, China * Author to whom correspondence should be addressed; E-Mail: xiaopg@; Tel./Fax: +86-010-6289-4462. Received: 9 April 2012; in revised form: 26 April 2012 / Accepted: 27 April 2012 / Published: 9 May 2012 Abstrat: Two new aryltetralin-type lignans, dolomiaeasin A (1) and dolomiaeasin B (2), were isolated from the roots of Dolomiaea souliei. Their structures were elucidated by means of various spectroscopic analyses. The cytotoxicities of 1 and 2 were tested by the MTT method, and both compounds showed no significant cytotoxic activities against the A549 and A2780 human cancer cell lines. This is the first time that aryltetralin-type lignans were isolated from the genus Dolomiaea. Keywords: Compositae; Dolomiaea souliei; aryltetralin; cytotoxicity 1. Introduction Dolomiaea souliei (Franch.) Shih belongs to the Dolomiaea genus in the family Compositae, and is mainly distributed in western Sichuan and eastern Tibet [1]. D. souliei is a traditional Chinese medicine which is well known for its medicinal uses in relieving pain and different indigenous diseases [2]. Previous studies indicated that D. souliei is a rich source of sesquiterpenes, triterpenes and lignans, some of which have been reported to exhibit an