Use of Intravenous Amiodarone in the Treatment of Nifekalant-Resistant Arrhythmia A Review of 11 Consecutive Cases with Severe Heart Failure 英文参考文献.docVIP

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Use of Intravenous Amiodarone in the Treatment of Nifekalant-Resistant Arrhythmia A Review of 11 Consecutive Cases with Severe Heart Failure 英文参考文献.doc

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Use of Intravenous Amiodarone in the Treatment of Nifekalant-Resistant Arrhythmia A Review of 11 Consecutive Cases with Severe Heart Failure 英文参考文献

Pharmaceuticals 2011, 4, 794-803; doi:10.3390/ph4060794 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Use of Intravenous Amiodarone in the Treatment of Nifekalant-Resistant Arrhythmia: A Review of 11 Consecutive Cases with Severe Heart Failure Koji Nakagawa 1, Kazufumi Nakamura 1,*, Kengo Fukushima Kusano 1, Satoshi Nagase 1, Takeshi Tada 1, Masato Murakami 1, Yoshiki Hata 1, Hiroshi Morita 1, Kunihisa Kohno 1,2, Kazumasa Hina 3, Tohru Ujihira 4, Tohru Ohe 1,5 and Hiroshi Ito 1 1 Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 7008558, Japan 2 Department of Cardiology, National Hospital Organization Iwakuni Medical Center, Iwakuni, 7400304, Japan 3 Department of Cardiology, Okayama Heart Clinic, Okayama, 7008558, Japan 4 Department of Cardiology, Okayama Redcross Hospital, Okayama, 7008558, Japan 5 Department of Cardiology, Cardiovascular Center Sakakibara Hospital, Okayama, 7008558, Japan * Author to whom correspondence should be addressed; E-Mail: ichibun@cc.okayama-u.ac.jp; Tel.: +81-86-235-7351; Fax: +81-86-235-7353. Received: 25 March 2011; in revised form: 25 May 2011 / Accepted: 27 May 2011 / Published: 31 May 2011 Abstract: Background: Both nifekalant hydrochloride (NIF), a selective IKr blocker, and intravenous amiodarone (AMD), a multi-channel (including IKr blocking) blocker, have been reported to be efficacious for refractory arrhythmias. However, the optimal use of those antiarrhythmic drugs for refractory arrhythmia with severe heart failure has not been established. Intravenous AMD might be effective for arrhythmias refractory to NIF in patients with severe heart failure. Here, we report that intravenous amiodarone was effective in the treatment of nifekalant-resistant in a group of arrhythmia patients with severe heart failure. Methods: Elev