甲状腺微小乳头状癌淋巴结转移特征及其影响因素分析.pdfVIP

l 浙江医学 di主磊EI 卷第.期 撼霜l 结 梁忠五可般地!段8第1鸣 越明 【摘要】 目的 分析甲状腺微小乳头状癌(papillary thyroid micorcarcinoma , PTMC )中淋巴结转移的临床特征，并对其影响 因素进行多因素分析。 方法 收集 2007 年 1 月至 2009 年 12 月 488 例经术后病理证实为 PTMC 患者的临床资料以及淋巴结转移 情况，分析 P丁MC 临床病理特征、肿瘤位置与淋巴结转移相关性，并采用 logistic 回归法对淋巴结转移的影响因素进行多因素分析。 结果 在 488 例经术后病理证实为 PTMC 患者中，132 例(27.0% )发生淋巴结转移，均未发现远处转移。 川、川、 IV、 V 区淋巴结转移率为 11.40/0 ，低于 VI 区淋巴结转移率 16.00/0( P0.01 ) 。 腺外侵犯组淋巴结转移率明显高于无腺外侵犯组(χ2=75.892 ,P0.01 ) 。 多因素 logistic 回归分析结果显示腺体外累犯和肿瘤位置为影响淋巴结转移的独立的影响因素。 结论 淋巴结转移是肿瘤分期的重要组成， 腺体外累犯和肿瘤位置为影响淋巴结转移的独立的影响因素，淋巴结转移的特征对于 PTMC 的治疗具有重要的参考价值。 【关键词】 甲状腺微小癌淋巴结转移 Clinical features of Iymph node metastasis of thyroid papillary microcarcinoma and its related factors LIANG Zhong , WANG Kejing, ZHAO Jianqiang, et al. Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China ( Abstract 】 Objective 丁o analyze the clinical features of Iymph node metastasis in thyroid papillary microcarcinoma and its related factors. Methods Clinical and pathological data of 488 patients with thyroid papillary microcarcinoma admitted from January 2007 to December 2009 were retrospectively analyzed , including 73 males and 415 females with a mean age of 45.1 ::f: 9.4. Statistical software SPSS 16.0, multivariate Logistic regression analysis were applied for data analysis. Results A- mong 488 cases Iymph node metastasis was confirmed by postoperative pathological examination in 132 cases(27 .00/0). The dis- tant metastases were not found. The Iymph node metastatic rate in 11 ，川 1 ， IV, V areas (11.40/0) was lower than that in area VI( 16.00/0, P = 0.001) . The Iymph node metastatic rate in extrothyroid group was significantly higher than that in non-extrothyroid group (86.1 % vs. 22.30/0 ， χ2= 75.892 , P0.01). Multivariate logistic regression analysis s