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Stampetal.ArthritisResearchTherapy2012,14:R138
/content/14/3/R138
RESEARCH ARTICLE
OpenAccess
Adenosinereceptorexpressioninrheumatoid
synovium:abasisformethotrexateaction
LisaKStamp1*,JodyHazlett2,RebeccaLRoberts3,ChristopherFrampton1,JohnHighton4andPaulAHessian2
Abstract
Introduction:Methotrexate(MTX)exertsatleastpartofitsanti-inflammatoryeffectsthroughadenosinereceptors
(ADOR).Theaimsofthisstudyweretodeterminetheexpressionofallfouradenosinereceptorgenes(ADORA1,
ADORA2A,ADORA2B,ADORA3andADORA3variant)inrheumatoidsynovialtissueandanyinfluenceofMTXexposure
onthisexpression.Furthermore,weinve
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