Annual Scientific Meeting, Edmonton, September 27-30, 2007.docVIP

MEETINGS ABSTRACTS AnnualScientificMeeting,Edmonton,September27–30, 2007 RhoKinaseUnderpinsAirwaySmoothMuscle HyperreactivityinNaiveCaveolin-1KnockoutMice bisindolylmaleimide and U0126 treatment, the effect was of equal magnitude on Cav-1 KO and B6129SF2/J mice, suggesting that the contribution of PKC and p42/p44 MAPK to contractile responses is not changed in Cav-1 KO mice. As we previously observed in vivo, Cav-1 KO mice exhibited a significant increase in Raw and tissue resistance (G). However, consistent with our ex vivo experiments, inhaled Y-27632 both decreased Raw and G and normaliz