分子生物学（张海红）CHAPTER 7.pptVIP

Regulation of chromatin structure Figure 7-38 Nucleosomes prefer to bind bent DNA. Specific DNA sequences can position nucleosomes. Because the DNA is bent severely during association with the nucleosome, DNA sequences that position nucleosomes are intrinsically bent. A:T base pairs have an intrinsic tendency to bend toward the minor groove and G:C base pairs have the opposite tendency. Sequences that altermate between A:T and G:C-rich sequences with a periodicity of ~5 bp Will act as preferred nucleosome binding sites. Particular DNA Sequences (3) Modification of the N-terminal tails of the