Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.docVIP

Kloostermanetal.GenomeBiology2011,12:R103 /2011/12/10/R103 RESEARCH OpenAccess Chromothripsisisacommonmechanismdriving genomicrearrangementsinprimaryand metastaticcolorectalcancer WigardPKloosterman1,MarlousHoogstraat1,2,OscarPaling2,MasoumehTavakoli-Yaraki1,IvoRenkens1, JoostSVermaat2,MarkusJvanRoosmalen1,StefvanLieshout1,2,IsaacJNijman3,WijnandRoessingh2, Rubenvan‘tSlot1,JosévandeBelt1,VictorGuryev3,MarcoKoudijs2,EmileVoest2andEdwinCuppen1,3* Abstract Background:Structuralrearrangementsformamajorclassofsomaticvariationincancergenomes.Local chromosomeshattering,termedchromothripsis,isamecha