Circadian Changes in the Sputum of Asthmatic Subjects and Healthy Controls.docVIP

ORIGINALSTUDY CircadianChangesintheSputumofAsthmaticSubjects andHealthyControls TodorA.Popov,MD,PhD,*MohamedS.Shenkada,MD,*AnnaV.Tzoncheva,MD,PhD,** MariaP.Pravtchanska,MD,*TihomirB.Mustakov,MD,*andVasilD.Dimitrov,MD,PhD* asarelativelysimpleandlessexpensiveapproach,affordable Background:Asthmaisexhibitingclassicalcircadian?uctuationsof to wider numbers of researchers and clinicians. Among its clinicalsymptomsandair?owmeasurements,presumablyin?uenced advantagesisthepossibilitytomakeserialmeasurementsto bytheunderlyingairwayin?ammationandtheendogenouscortisol ?ag the time points of naturally o