Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis.docVIP

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Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis.doc

Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis

Coulthardetal.ArthritisResearchTherapy2011,13:R42 /content/13/2/R42 RESEARCH ARTICLE OpenAccess Comparativeefficacyofasecretory phospholipaseA2inhibitorwithconventional anti-inflammatoryagentsinaratmodelof antigen-inducedarthritis LiamGCoulthard,JaclynCostello,BrentRobinson,IanAShiels,StephenMTaylorandTrentMWoodruff* Abstract Introduction:Previously,secretoryphospholipaseA2(sPLA2)inhibitionhasbeenusedasanadjunctto conventionalrheumatoidarthritistherapyinhumanclinicaltrialswithoutsignificantimprovementofarthritic pathology.Inthisstudy,wecomparedtheefficacyofapotentandorallyactivegroupIIasecret

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