Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice.docVIP

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Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice.doc

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Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice

Cough BioMedCentral Research Open Access Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice Junzo Kamei*, Yuji Yoshikawa and Akiyoshi Saitoh Address: Department of Pathophysiology Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo 142–8501, Japan Email: Junzo Kamei* - kamei@hoshi.ac.jp; Yuji Yoshikawa - y-yoshikawa@nikken-chemicals.co.jp; Akiyoshi Saitoh - a-saitoh@hoshi.ac.jp * Corresponding author Published: 30 March 2006 Received: 12 October 2005 Accepted: 30 March 2006 Cough2006, 2:2 doi:10.1186/1745-9974-2-2 This article is available from: /content/2/1/2 ? 2006Kamei et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Several observations have suggested that anandamide, an endogenous cannabinoid ligand, plays an important role in the modulation of cough sensitivity. However, it is unknown whether the anandamide membrane transporter plays a role in this modulation. To test this hypothesis, we investigated the effects of VDM11, an anandamide membrane transporter inhibitor, on capsaicin- and anandamide-induced cough. Methods: The effect of VDM11, an anandamide membrane transporter inhibitor, on capsaicin- and anandamide- induced cough in mice was examined. Results: VDM11, at doses of 3–10 mg/kg subcutaneously, produced a dose-dependent antitussive effect. This antitussive effect was antagonized by pretreatment with either intraperitoneal administration (3 mg/kg) or inhalation (1 mg/ml) of SR141716A, a cannabinoid receptor (CB1) antagonist. However, intracerebroventricular injection of SR141716A (0.03 mg/mouse) did not alter t