Effects of Astragaloside IV on heart failure in rats.docVIP

Chinese Medicine BioMedCentral Research Open Access Effects of Astragaloside IV on heart failure in rats Zhuanyou Zhao*1, Weiting Wang1, Fang Wang2, Kerui Zhao3, Yingmei Han1, Weiren Xu1 and Lida Tang*1 Address: 1State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, PR China, 2Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China and 3Department of Pharmacy, Tianjin Medical College, Tianjin 300222, PR China Email: Zhuanyou Zhao* -163.com; Weiting Wang - wangweiting2000@163.com; Fang Wang - wangfang0322@; Kerui Zhao - kerui@; Yingmei Han - Yingmei-tcmch405@163.com; Weiren Xu - Weiren-xwrtj@; Lida Tang* - tangld@163.net * Corresponding authors Published: 2 April 2009 Received: 12 October 2007 Accepted: 2 April 2009 Chinese Medicine 2009, 4:6 doi:10.1186/1749-8546-4-6 This article is available from: /content/4/1/6 ? 2009 Zhao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Astragaloside IV (ASI) in Radix Astragali is believed to be the active component in treating heart failure. The present study aims to examine the effects of ASI on cardiovascular parameters in long-term heart failure in rats. Methods: Using echocardiographic and haemodynamic measurements, we studied the effects of ASI on congestive heart failure (CHF) induced by ligation of the left coronary artery in rats. Results: ASI (0.1, 0.3 and 1.0 mg/kg/day) attenuated the decline of fractional shortening (FS). The peak derivatives of the left ventricle (LV) pressure (dp/dt) in ASI-treated groups significantly increased. Both LV internal diameters in dia