Effects of hypertonic saline solution and pentoxifylline on rat mesenteric microcirculation after hemorrhagic shockreperfusion followed by cecal ligationpuncture an intravital microscopic study.docVIP

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Effects of hypertonic saline solution and pentoxifylline on rat mesenteric microcirculation after hemorrhagic shockreperfusion followed by cecal ligationpuncture an intravital microscopic study.doc

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Effects of hypertonic saline solution and pentoxifylline on rat mesenteric microcirculation after hemorrhagic shockreperfusion followed by cecal ligationpuncture an intravital microscopic study

Available online /supplements/11/S3 Critical Care Volume 11 Suppl 3, 2007 Fourth International Symposium on Intensive Care and Emergency Medicine for Latin America S?o Paulo, Brazil, 20–23 June 2007 Published online: 19 June 2007 These abstracts are online at /supplements/11/S3 ? 2007 BioMed Central Ltd Basic science Reference 1. Janiszewski M, Do Carmo AO, Pedro MA, et al.: Crit Care Med 2004, 32:818-825. P1 P2 Platelet-derived exosomes are redox signaling particles Which is the worst factor in sepsis aggravation: translocated bacterial amount or gut-associated lymphoid tissue activation? MH Gambim1, AO Carmo2, L Marti2, S Veríssimo-Filho1, LR Lopes1, M Janiszewski1,2 1Faculdade de Medicina and Instituto de Ciências Biomédicas, University of S?o Paulo – SP, Brazil; 2Instituto Israelita de Ensino e IHJ Koh1, JL Menchaca-Diaz2, AMA Liberatore2, MY Taki1, U Fagundes-Neto2, J Francisco Jr1 Pesquisa, Albert Einstein Hospital, S?o Paulo – SP, Brazil Critical Care 2007, 11(Suppl 3):P1 (doi: 10.1186/cc5788) 1Department of Surgery and 2Department of Pediatrics, Federal University of S?o Paulo – SP, Brazil Critical Care 2007, 11(Suppl 3):P2 (doi: 10.1186/cc5789) Sepsis, the body’s response to infection, is associated with extremely high mortality rates. Why a protective mechanism turns into a deadly clinical picture is a matter of debate, and goes largely unexplained. In previous work we demonstrated that platelet-derived microparticles (MP) can induce endothelial and vascular smooth muscle cell apoptosis in septic patients through NADPH oxidase- dependent superoxide release [1]. In this work we sought to create a model for ex vivo generation of septic-like MP and to identify the pathways responsible for MP free radical release and effects. Septic shock is a condition related to the generation of high amounts of thrombin, TNFα and nitrogen reactive species. Human Introduction The intestinal hypothesis of se