Effects of respiratory mechanics on the capnogram phases importance of dynamic compliance of the respiratory system.docVIP
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Effects of respiratory mechanics on the capnogram phases importance of dynamic compliance of the respiratory system
Babiketal.CriticalCare2012,16:R177
/content/16/5/R177
RESEARCH
OpenAccess
Effectsofrespiratorymechanicsonthe
capnogramphases:importanceofdynamic
complianceoftherespiratorysystem
BarnaBabik1,ZsófiaCsorba1,DorottyaCz?vek2,PatrickNMayr3,GáborBogáts4andFerencPeták2*
Abstract
Introduction:TheslopeofphaseIIIofthecapnogram(SIII)relatestoprogressiveemptyingofthealveoli,a
ventilation/perfusionmismatch,andventilationinhomogeneity.SIII dependsnotonlyontheairwaygeometry,but
alsoonthedynamicrespiratorycompliance(Crs);thislattereffecthasnotbeenevaluated.Accordingly,we
establishedthevalueofSIII formonitoringairwayresistanceduringmechanicalventilation.
Methods:Sidestreamcapnographywasperformedduringmechanicalventilationinpatientsundergoingelective
cardiacsurgery(n=144).Theairwayresistance(Raw),totalrespiratoryresistanceandCrsdisplayedbythe
ventilator,thepartialpressureofarterialoxygen(PaO2)andSIII weremeasuredintimedomain(ST-III)andina
smallercohort(n=68)byvolumetry(SV-III)withandwithoutnormalizationtotheaverageCO2phaseIII
concentration.Measurementswereperformedatpositiveend-expiratorypressure(PEEP)levelsof3,6and9
cmH2Oinpatientswithhealthylungs(GroupHL),andinpatientswithrespiratorysymptomsinvolvinglow(Group
LC),medium(GroupMC)orhighCrs(GroupHC).
Results:ST-III andSV-III exhibitedsimilarPEEPdependenciesanddistributionbetweentheprotocolgroupsformed
onthebasisofCrs.AwideinterindividualscatterwasobservedintheoverallRaw-ST-III relationship,whichwas
primarilyaffectedbyCrs.DecreasesinRawwithincreasingPEEPwerereflectedinsharpfallsinSIII inGroupHC,
andinmoderatedecreasesinSIII inGroupMC,whereasST-III wasinsensitivetochangesinairwaycaliberinGroups
LCandHL.
Conclusions:SIII assessedinthetimedomainandbyvolumetryprovidemeaningfulinformationaboutalterations
inairwaycaliber,butonlywithinanindividualpatient.AlthoughST-III maybeofvalueforbedsidemonitoringof
theairwayproperties,itssensitivitydependsonCrs.Thus,assessmentofthecapnogramshapeshouldalwaysbe
coupledwith
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