Efficacy of two once-daily methylphenidate formulations compared across dose levels at different times of the day Preliminary indications from a secondary analysis of the COMACS study data.docVIP

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Efficacy of two once-daily methylphenidate formulations compared across dose levels at different times of the day Preliminary indications from a secondary analysis of the COMACS study data.doc

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Efficacy of two once-daily methylphenidate formulations compared across dose levels at different times of the day Preliminary indications from a secondary analysis of the COMACS study data

BMC Psychiatry BioMedCentral Research article Open Access Efficacy of two once-daily methylphenidate formulations compared across dose levels at different times of the day: Preliminary indications from a secondary analysis of the COMACS study data Edmund JS Sonuga-Barke?1, James M Swanson?2, David Coghill?3, Heleen H DeCory*?4 and Simon J Hatch?4 Address: 1The Developmental Brain-Behaviour Unit, University of Southampton, Southampton, SO17 1BJ. UK, 2Child Development Center, University of California at Irvine, Irvine, CA 19722. USA, 3The Department of Psychiatry, The University of Dundee, Dundee, DD1 9SY. UK and 4Medical and Regulatory Affairs, Celltech Americas, Inc., Rochester, NY 14603. USA Email: Edmund JS Sonuga-Barke - ejb3@soton.ac.uk; James M Swanson - jmswanso@; David Coghill - david.coghill@tpct.scot.nhs.uk; Heleen H DeCory* - heleen.decory@; Simon J Hatch - simon.hatch@ * Corresponding author ?Equal contributors Published: 30 September 2004 Received: 09 June 2004 Accepted: 30 September 2004 BMC Psychiatry 2004, 4:28 doi:10.1186/1471-244X-4-28 This article is available from: /1471-244X/4/28 ? 2004 Sonuga-Barke et al; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Methylphenidate (MPH) is commonly prescribed in the treatment of Attention-Deficit/ Hyperactivity Disorder or ADHD. Concerta and Metadate CD are once-daily formulations of MPH using different delivery mechanisms resulting in different pharmacokinetic profiles. A recent study (COMACS) showed that for near-milligram (mg) equivalent daily doses, Metadate CD provides greater symptom control in the morning (1.5 through 4.5 hours post-dose), while Concerta provides greater control in the early evening (12 hours post-d