Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models.docVIP

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Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models.doc

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Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

Molecules 2010, 15, 1223-1231; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models Karel ?mejkal 1,*, Tereza ?lapetová 1, Pavel Krmen?ík 1, Renata Kubínová 1, Pavel Suchy 2, Stefano Dall′Acqua 3, Gabbriella Innocenti 3, Ján Van?o 4, Karolína Kalvarová 1, Margita Dvorská 1, Ji?í Slanina 5, Eva Kramá?ová 1, Jan Muselík 6 and Milan ?emli?ka 1 1 Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 2 Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 3 Department of Pharmaceutical Sciences, University of Padua, Padua, Italy 4 Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 5 Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czech Republic 6 Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic ? Author to whom correspondence should be addressed; E-Mail: karel.mejkal@post.cz. Received: 14 January 2010; in revised form: 5 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010 Abstract: The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan- induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested. Keywords: Schisandra chinensis; dibenzocyclooctadiene l