Evaluation of the Combined Effects of Stilbenoid from Shorea gibbosa and Vancomycin against Methicillin-Resistant Staphylococcus aureus (MRSA).docVIP

Evaluation of the Combined Effects of Stilbenoid from Shorea gibbosa and Vancomycin against Methicillin-Resistant Staphylococcus aureus (MRSA).doc

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Evaluation of the Combined Effects of Stilbenoid from Shorea gibbosa and Vancomycin against Methicillin-Resistant Staphylococcus aureus (MRSA)

Pharmaceuticals 2012, 5, 1032-1043; doi:10.3390/ph5091032 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Evaluation of the Combined Effects of Stilbenoid from Shorea gibbosa and Vancomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Dayang Fredalina Basri 1,*, Chan Kin Luoi 1, Abdul Muin Azmi 1 and Jalifah Latip 2 1 School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; E-Mails: chankinluoi@ (C.K.L.); muinpmukm@ (A.M.A.) 2 Centre of Chemical Science and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, 43600 Bangi Selangor, Malaysia; E-Mail: jali@ukm.my * Author to whom correspondence should be addressed; E-Mail: dayang@medic.ukm.my; Tel.: +602-9289-7652; Fax: +603-2692-9032. Received: 18 July 2012; in revised form: 3 September 2012 / Accepted: 12 September 2012 / Published: 20 September 2012 Abstract: The aim of this study is to determine the combined effects of stilbenoids from Shorea gibbosa and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA). A total of nine pure compounds, five stilbenoid dimers ε-viniferin, ampelopsin A, balanocarpol, laevifonol and diptoindonesin G and four stilbenoid trimers ?-viniferin, johorenol A, ampelopsin E and vaticanol G were evaluated for their antibacterial activities against ATCC 33591 and a HUKM clinical isolate. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for each active compound were determined using the serial microdilution and plate-streak techniques. The combined effect of stilbenoids with vancomycin against MRSA was evaluated using the checkerboard assay to determine their fractional inhibitory concentration (FIC) index values. The MIC value of ?-viniferin on both MRSA strains was 100 μg/mL, whereas those of johoreno

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