Evidence from comparative genomics for a complete sexual cycle in the asexual pathogenic yeast Candida glabrata.docVIP

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Evidence from comparative genomics for a complete sexual cycle in the asexual pathogenic yeast Candida glabrata.doc

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Evidence from comparative genomics for a complete sexual cycle in the asexual pathogenic yeast Candida glabrata

Open Access Research Evidence from comparative genomics for a complete sexual cycle in the ‘asexual’ pathogenic yeast Candida glabrata Simon Wong*, Mario A Fares*, Wolfgang Zimmermann?, Geraldine Butler? and Kenneth H Wolfe* Addresses: *Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland. ?AGOWA, Glienicker Weg 185, D-12489 Berlin, Germany. ?Department of Biochemistry and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. Correspondence: Kenneth H Wolfe. E-mail: khwolfe@tcd.ie Published: 23 January 2003 Received: 4 October 2002 Revised: 19 November 2002 Accepted: 4 December 2002 Genome Biology 2003, 4:R10 The electronic version of this article is the complete one and can be found online at /2003/4/2/R10 ? 2003 Wong et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Candida glabrata is a pathogenic yeast of increasing medical concern. It has been regarded as asexual since it was first described in 1917, yet phylogenetic analyses have revealed that it is more closely related to sexual yeasts than other Candida species. We show here that the C. glabrata genome contains many genes apparently involved in sexual reproduction. Results: By genome survey sequencing, we find that genes involved in mating and meiosis are as numerous in C. glabrata as in the sexual species Kluyveromyces delphensis, which is its closest known relative. C. glabrata has a putative mating-type (MAT) locus and a pheromone gene (MFALPHA2), as well as orthologs of at least 31 other Saccharomyces cerevisiae genes that have no known roles apart from mating or meiosis, including FUS3, IME1 and SMK1. Conclusions: We infer that C.